https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14536 500 ms was defined as abnormal. Results: Forty-six patients had Holter recordings after 10–40 mg droperidol and 316 QT–HR pairs were included. There were 32 abnormal QT measurements in four patients, three given 10 mg and one 20 mg. In three of the four patients QTcF >500 ms but only in one taking methadone was the timing of QTcF >500 ms consistent with droperidol dosing. Of the three other patients, one took amphetamines, one still had QT prolongation 24 h after droperidol and one took a lamotrigine overdose. No patient given >30 mg had a prolonged QT. There were no arrhythmias. Conclusion: QT prolongation was observed with high dose droperidol. However, there was little evidence supporting droperidol being the cause and QT prolongation was more likely due to pre-existing conditions or other drugs.]]> Wed 11 Apr 2018 11:05:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14404 Wed 11 Apr 2018 10:15:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11519 Sat 24 Mar 2018 08:10:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28152 Sat 24 Mar 2018 07:36:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29671 –1 provided a stable model and lowest objective function. This represents extremely rapid absorption with a half-life of 5 min. The final model had a clearance of 41.9 l h^–1 and volume of distribution of the central compartment of, 73.6 l. Median and interquartile range of initial (alpha) half-life was 0.32 h (0.26–0.37 h) and second (beta) half-life was 3.0 h (2.5–3.6 h). Simulations indicate that 10 mg alone provides an 80% probability of being above the lower limit of quantification (5 μg l^–1) for 7 h, 2 h longer than for 5 mg. Giving two 10 mg doses increased this duration to 10 h. Conclusions: Intramuscular droperidol is rapidly absorbed with high therapeutic concentrations after 5 and 10 mg doses, and supports clinical data in which droperidol sedates rapidly for up to 6 h.]]> Sat 24 Mar 2018 07:32:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26936 Sat 24 Mar 2018 07:27:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34254 Fri 22 Feb 2019 16:55:18 AEDT ]]>